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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight-loss in addition to a reduced-calorie diet and exercise.

Using two separate drugs to lose weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err to the side of caution and permit the FDA do its job and demand some investigation be done in order that the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on their medications.

Researchers found out that participants using this drug for any year, lost weight within 4 weeks and have kept the weight off through the entire 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which may make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular is the fact that by right now there are no long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartbeat, and shouldn't be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


The most common adverse reactions reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.